Terms of Use. Call your doctor or health care professional if you are unable to keep an appointment. You should talk with your doctor if you develop any mild side effects that concern you. It is based on denosumab and calcium (the active ingredients of Prolia and Calcium, respectively), and Prolia and Calcium (the brand names). Follow your doctor's instructions about any restrictions on food, beverages, or activity. Youll receive Prolia doses from a healthcare professional. Be sure to read this information carefully each time. See your dentist regularly. Problem absorbing minerals. Low blood calcium level. What is the most important information I should know about Prolia? Keep out of the reach of children and pets. If you have low blood calcium, it may get worse during treatment. In rare cases, your doctor may have you self-inject Prolia at home. It works with your immune system to help prevent bone loss. As with most drugs, Prolia can cause an allergic reaction in some people. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. But weight gain may be a symptom of a side effect called peripheral edema. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. * Symptoms can include: flushing (temporary warmth, redness, or deepening of skin color), swelling under your skin, typically in your lips, eyelids, feet, or hands, swelling of your mouth, tongue, or throat, which can make it hard to breathe. Your risk for some health conditions increases when you are postmenopausal. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. Prolia may not be right for you if you have certain medical conditions or other factors that affect your health. Tell your doctor if youd like to know more about these drugs. Patients should not stop Prolia treatment without first consulting your If you notice any tooth or jaw pain, or sensitivity while using Prolia, talk with your doctor or dentist right away. If your dizziness doesnt go away or becomes severe, talk with your doctor. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). You will receive your Prolia injection from your healthcare provider at a their office or clinic. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. that's no different than scheduling a visit to the dentist twice a year. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. But theyre each effective in treating osteoporosis and preventing bone loss. such as inflammation of your skin (dermatitis), rash, and eczema have been reported. This is not a complete list of warnings for Prolia. So, dont be afraid to ask questions or offer feedback on your treatment. There are no known interactions with Prolia and other medications, supplements, or other products. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. Compared to other osteoporosis treatments, only Proliais1 shot every 6 months. (To learn more, see the Side effect specifics section above.). They can give you more details about this possible side effect and suggest ways to manage it. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Its recommended that calcium and vitamin D supplements be taken with Prolia. How long will the side effects of Prolia last? The lists below describe some of the more common side effects that Prolia may cause. Your doctor will explain how Prolia will be given to you. And some of these side effects are more common with certain uses of Prolia. They may also suggest exercises to help improve your bone strength and lower your risk for fractures and osteoporosis. This may include acetaminophen (Tylenol), naproxen (Aleve), or ibuprofen (Advil, Motrin). Follow your doctor's instructions. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Specifically, Prolia is a monoclonal antibody (a lab-made protein). Phase IV trials are used to detect adverse drug outcomes and monitor drug effectiveness in the real world. Bone pain from Prolia may be most noticeable in your arms and legs. Check with your doctor if you have more questions about these drugs. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. Prolia injections administered by a healthcare professional. For Prolia, talk to your pediatrician regarding the use of this medicine in children. Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. And if you have osteoporosis, falling could increase your risk of fractures. pain in bones and muscles, including back, arm, and leg pain, pain or swelling in the thigh or groin area. What should I know about Prolia vs. Fosamax? The two most common forms of arthritis are osteoarthritis and rheumatoid arthritis (RA). If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Rare, long-term side effects of Prolia include fractures of the spine or femur (thighbone). Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. Prolia can cause many serious side effects. Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium. And some of these side effects are more common with certain uses of Prolia. It could harm the unborn baby or cause birth defects. Policy. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Use of the term female in this article refers to sex assigned at birth. * For more information about this side effect, see Side effect specifics below. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. Specifically, Prolia works by blocking a protein called RANK. The list below may not include all possible serious side effects of the drug. To help prevent low calcium, your healthcare provider may also Prolia was the right choice for me because it worked for me and it was 1 shot every 6 months. Any advice? It is given by a health care professional in a hospital or clinic setting. If they find any cavities or infection, theyll typically delay having you receive Prolia until your dental problems are treated. But its not clear whether this side effect occurred in clinical studies. If your pain becomes severe, your doctor may recommend other treatment options to replace Prolia. Call your doctor for medical advice about side effects. With arthritis, you have pain and inflammation of your joints. Prolia is an injection prescribed for certain adults with osteoporosis, which Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. kidney disease (or if you are on dialysis); a weak immune system (caused by disease or by using certain medicines); hypoparathyroidism (decreased functioning of the parathyroid glands); any condition that makes it hard for your body to absorb nutrients from food (malabsorption); if you are scheduled for a dental procedure; if you cannot take daily calcium and vitamin D; or. But this isnt the case with Prolia. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. Do not stop, skip or delay taking Prolia without first talking with your doctor. 12 Low serum calcium levels should be corrected before starting denosumab; supplemental calcium and vitamin D is required in patients predisposed to hypocalcaemia (see Ensure adequate calcium and vitamin D intake ). Its thought that hair loss could occur due to how Prolia affects your immune system. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments But it can increase your risk of serious health problems, such as heart attack. They can tell you more about benefits and risks of Prolia and Forteo. Musculoskeletal pain refers to pain in your bones, muscles, tendons, and ligaments. While youre taking Prolia, your healthcare provider will also strongly suggest taking at least 1000 mg of calcium and 400 international units (IU) of vitamin D daily to prevent hypocalcemia or low calcium levels. We avoid using tertiary references. Talk with your doctor about the risks of using this drug during pregnancy. Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. You should take calcium and vitamin D as your doctor tells you to while you receive Prolia. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. Store in the original container away from heat and light. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. Healthline Media does not provide medical advice, diagnosis, or treatment. (BMD is a measurement of the amount of minerals such as calcium in your bones.) With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. It is advisable to take 2 capsules in the morning with food and 1 in the evening also with food. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. RA is an autoimmune condition in which your immune system attacks your joints. If you have any questions about Prolias side effects, talk with your doctor. This medicine is only given in a clinic, doctor's office, or other health care setting and will not be stored at home. Take only the amount of calcium and vitamin D that your doctor has prescribed. eHealthMe is studying from 146,783 Calcium users for its effectiveness, alternative drugs and more. Learn how to increase or maintain bone density here. have happened in people who take Prolia. Prolia (denosumab) injection, for subcutaneous use. If you receive Prolia, you should not receive XGEVA. Before beginning treatment with Prolia, ask your doctor about the benefits and risks of the drug. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. A biologic drug is made from parts of living organisms. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. These lists dont include all possible side effects. If your pain is more severe, your doctor may suggest prescription pain medication or physical therapy. For example, if you have a serious UTI or other infection, call your doctor right away. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. For example, in the studies, people taking Prolia for up to 8 years didnt have significant side effects compared with people taking a placebo. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Common Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. The risk is real, but rare. But, in some cases, alcohol can affect your balance and increase your risk for falls. Do not become pregnant while taking this medicine or for 5 months after stopping it. Discuss the foods you eat and the vitamins you take with your health care professional. It is created by eHealthMe based on reports of 8,432 people who take Prolia and Calcium from the FDA, and is updated regularly. This is because its not known if Prolia is safe to receive while breastfeeding. This could include having: Before taking Prolia, share your dental history with your doctor. Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. So be sure to tell your doctor about all your health conditions before taking Prolia. Call your doctor at once if you have a fever, chills, pain or burning when you urinate, severe stomach pain, cough, shortness of breath, skin problems, numbness or tingling, severe or unusual pain, or skin problems. (2022). For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below. Patient testimonials represent individual experiences with Prolia. Copyright 1996-2023 Cerner Multum, Inc. In addition, your doctor will most likely recommend that you take calcium and vitamin D supplements while taking bisphosphonates, since vitamin D helps your body to absorb calcium. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. For information about the difference between sex and gender, see this article. What Health Changes Should You Expect Postmenopause? Some research has shown that alcohol consumption may increase your risk of osteoporosis, a bone fracture or impaired healing after a fracture. Tell your doctor right away if you become pregnant while taking Prolia. For a basic overview of Prolia, including details about its uses, see this article. These treatments may include acetaminophen (Tylenol) or ibuprofen (Advil, Motrin). I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. Drug interactions are reported among people who take Prolia and Calcium. See what this means for you in the chart below. Allergic reaction. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, In Conversation: Investigating the power of music for dementia, 11 ways to increase bone density naturally, 14 of the best calcium supplements in 2023. You should always consult your doctor or another healthcare professional before taking any medication. Prolia may cause serious side effects. Prolia contains the active ingredient denosumab. If you have low calcium levels, you should not take Prolia. WebIn many individuals, calcium supplements are better absorbed when taken with food. But if you think youre having a medical emergency, call 911 or your local emergency number. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not shake the prefilled syringe. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. Use of the terms female and male in this article refers to sex assigned at birth. See additional information. They may want to check for other causes. (A low blood calcium level is a possible side effect of Prolia.). If you develop hypocalcemia, your doctor will typically have you stop using Prolia. Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. Prolia also has other uses, which are described in the next section below. All rights reserved. Prolia may cause serious side effects. Youll receive Prolia from a healthcare professional as an injection under the skin in one of the following areas: Prolia contains the active drug denosumab, which is a biologic medication. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. If you are a healthcare professional, click "I Agree" to continue. Your doctor can provide more information to you about the benefits and risks of using Prolia for your condition. The fractures may require surgeries, take several months to heal, or both. Osteoporosis Is Common in Older Men, Know the Risks, Your Guide to Osteoporosis and Broken Bones: Know Your Risks, 7 Things You Can Do Today to Prevent Osteoporosis, treat osteoporosis in males* and in females* whove gone through, treat osteoporosis caused by long-term use of, increase bone mass in females using certain, increase bone mass in males using certain treatments for, increased risk of bone fracture after stopping Prolia treatment, such as having multiple, severe pain in your joints, bones, and muscles, skin-related side effects, such as rash, dry skin, or blisters, decreased bone production, which means your bones take longer to make new bone tissue, dental problems and jaw-related side effects*, jaw necrosis (death of tissue in the jawbone), Prolias active ingredient is denosumab. Prolia comes as a solution thats given as an injection under your skin. You can use the study as a second opinion to make health care decisions. (To learn more, see the Precautions for Prolia section below.). These types of medications come in forms that are taken by mouth and forms that are given by injection. There is a potential for serious side effects to an unborn child. We comply with the HONcode standard for trustworthy health information. (2021). Also, its important to brush and floss your teeth regularly while youre using Prolia. Talk with your doctor about which other treatments are better choices for you. You should not receive Prolia if you are allergic to denosumab, or if you in your skin, lower stomach area (abdomen), bladder, or ear may happen. All information is observation-only. If your levels are high, theyll typically recommend lifestyle changes and medication. Xgeva is also used to treat giant cell tumor of the bone. What should I know about Prolia vs. Xgeva? But Prolia is given once every 6 months by a healthcare professional. Learn more about some of the side effects Prolia may cause. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. For instance, if you have a health condition that causes excess calcium in You may need to have a negative pregnancy test before starting this treatment. Prolia 60 mg/1 mL in a single-dose prefilled syringe (medicine). If you keep this medicine at home, store it in the original carton in a refrigerator. What should I know about Prolia vs. Evenity? No, weight gain wasnt reported as a side effect of Prolia in clinical trials. Breastfeeding. Prolia may lower the calcium levels in your blood. They can suggest ways to help relieve these side effects. For more information about how Prolia and Zometa compare with each other, see this article. Both are prescription medicines. And in my mind, that's no different than scheduling a visit to the dentist twice a year. It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. They may recommend ways to ease your symptoms and determine whether you should keep taking Prolia. Denosumab is contraindicated in women with hypocalcaemia. Do not share this medicine with others. If youre breastfeeding, you should not receive Prolia. It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. Find out what it means, how its calculated, and more. Patients in the study may take other drugs besides Prolia and Calcium. These side effects may be temporary, lasting a few days or weeks. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. You may need to stop using the medicine for a short time. Youll likely have questions about your condition and treatment choices. Boniva contains the active drug ibandronate, but Prolia contains the active drug denosumab. Studies of Prolia didnt report weight gain as a side effect of the drug. To learn more about these two drugs, check out this drug article. But if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. Vitamin D The body needs vitamin D to absorb calcium. Youll likely receive Prolia long term if you and your doctor decide that the drug is effective and safe for you. Mild side effects that have been reported with Prolia include: These side effects may be temporary, lasting a few days or weeks. What should I know about Prolia vs. Boniva? Before you receive Prolia, tell your doctor if you have kidney disease (or if you are on dialysis), a weak immune system, a history of hypoparathyroidism or thyroid surgery, a history of intestinal surgery, a condition that makes it hard for your body to absorb nutrients from food, or if you are allergic to latex. And you should continue using birth control for at least 5 months after stopping Prolia. If you cant properly absorb calcium or other minerals, be sure to talk with your doctor before using Prolia. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. may occur. Prolia is a prescriptionmedicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body. If you develop high cholesterol with Prolia, your doctor can guide you on which treatment options are right for your condition. But if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. Prescribing Information and Because these reports happened after the studies, it isnt known for sure whether Prolia caused hair loss, or if it was due to another reason. Serious side effects that have been reported and their symptoms include: * To learn more, see Does Prolia cause long-term side effects? in the FAQs about the side effects of Prolia section below. We link primary sources including studies, scientific references, and statistics within each article and also list them in the resources section at the bottom of our articles. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Youll receive 60 mg/mL of Prolia once every 6 months. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider.
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